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Epilepsy, Tonic-Clonic, Symptomatic

MedGen UID:
152948
•Concept ID:
C0751119
•
Disease or Syndrome
Synonyms: Epilepsies, Symptomatic Tonic-Clonic; Epilepsy, Symptomatic Tonic-Clonic; Symptomatic Tonic Clonic Epilepsy; Symptomatic Tonic-Clonic Epilepsies; Symptomatic Tonic-Clonic Epilepsy; Tonic-Clonic Epilepsies, Symptomatic; Tonic-Clonic Epilepsy, Symptomatic

Professional guidelines

PubMed

Dravet syndrome: Advances in etiology, clinical presentation, and treatment.
He Z, Li Y, Zhao X, Li B
Epilepsy Res 2022 Dec;188:107041. Epub 2022 Oct 29 doi: 10.1016/j.eplepsyres.2022.107041. PMID: 36368227
Treatment of idiopathic generalized epilepsy - a review of the evidence.
Beydoun A, D'Souza J
Expert Opin Pharmacother 2012 Jun;13(9):1283-98. Epub 2012 May 9 doi: 10.1517/14656566.2012.685162. PMID: 22568658
When to start drug treatment for childhood epilepsy: the clinical-epidemiological evidence.
Arts WF, Geerts AT
Eur J Paediatr Neurol 2009 Mar;13(2):93-101. Epub 2008 Jun 24 doi: 10.1016/j.ejpn.2008.02.010. PMID: 18567515

Recent clinical studies

Etiology

Focal cortical dysplasia links to sleep-related epilepsy in symptomatic focal epilepsy.
Wang Y, He C, Chen C, Wang Z, Ming W, Qiu J, Ying M, Chen W, Jin B, Li H, Ding M, Wang S
Epilepsy Behav 2022 Feb;127:108507. Epub 2021 Dec 27 doi: 10.1016/j.yebeh.2021.108507. PMID: 34968776
Nonconvulsive status epilepticus in the elderly.
Dupont S, Kinugawa K
Rev Neurol (Paris) 2020 Nov;176(9):701-709. Epub 2020 Mar 10 doi: 10.1016/j.neurol.2019.12.007. PMID: 32169326
The Epidemiology of Epilepsy.
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Sudden unexpected death in epilepsy.
Duncan S, Brodie MJ
Epilepsy Behav 2011 Aug;21(4):344-51. Epub 2011 Jun 12 doi: 10.1016/j.yebeh.2011.04.056. PMID: 21665551
Mortality in epilepsy.
Hitiris N, Mohanraj R, Norrie J, Brodie MJ
Epilepsy Behav 2007 May;10(3):363-76. Epub 2007 Mar 6 doi: 10.1016/j.yebeh.2007.01.005. PMID: 17337248

Diagnosis

Familial adult myoclonus epilepsy: a pragmatic approach.
Cherian A, Divya KP, Krishnan ARS
Acta Neurol Belg 2024 Apr;124(2):389-394. Epub 2023 Dec 19 doi: 10.1007/s13760-023-02432-6. PMID: 38114875
Nonconvulsive status epilepticus in the elderly.
Dupont S, Kinugawa K
Rev Neurol (Paris) 2020 Nov;176(9):701-709. Epub 2020 Mar 10 doi: 10.1016/j.neurol.2019.12.007. PMID: 32169326
The Epidemiology of Epilepsy.
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Status epilepticus.
Dulac O, Takahashi T
Handb Clin Neurol 2013;111:681-9. doi: 10.1016/B978-0-444-52891-9.00070-1. PMID: 23622215
Epilepsy.
Gilligan B
Aust Fam Physician 1979 Feb;8(2):179-94. PMID: 106817

Therapy

Dravet syndrome: Advances in etiology, clinical presentation, and treatment.
He Z, Li Y, Zhao X, Li B
Epilepsy Res 2022 Dec;188:107041. Epub 2022 Oct 29 doi: 10.1016/j.eplepsyres.2022.107041. PMID: 36368227
Nonconvulsive status epilepticus in the elderly.
Dupont S, Kinugawa K
Rev Neurol (Paris) 2020 Nov;176(9):701-709. Epub 2020 Mar 10 doi: 10.1016/j.neurol.2019.12.007. PMID: 32169326
Myoclonus and seizures in progressive myoclonus epilepsies: pharmacology and therapeutic trials.
Michelucci R, Pasini E, Riguzzi P, Andermann E, Kälviäinen R, Genton P
Epileptic Disord 2016 Sep 1;18(S2):145-153. doi: 10.1684/epd.2016.0861. PMID: 27629998
Sudden unexpected death in epilepsy.
Duncan S, Brodie MJ
Epilepsy Behav 2011 Aug;21(4):344-51. Epub 2011 Jun 12 doi: 10.1016/j.yebeh.2011.04.056. PMID: 21665551
Epilepsy.
Gilligan B
Aust Fam Physician 1979 Feb;8(2):179-94. PMID: 106817

Prognosis

Dravet syndrome: Advances in etiology, clinical presentation, and treatment.
He Z, Li Y, Zhao X, Li B
Epilepsy Res 2022 Dec;188:107041. Epub 2022 Oct 29 doi: 10.1016/j.eplepsyres.2022.107041. PMID: 36368227
Radiosurgical Corpus Callosotomy: A Review of Literature.
Tripathi M, Maskara P, Rangan VS, Mohindra S, De Salles AAF, Kumar N
World Neurosurg 2021 Jan;145:323-333. Epub 2020 Sep 3 doi: 10.1016/j.wneu.2020.08.205. PMID: 32891831
The Epidemiology of Epilepsy.
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Status epilepticus.
Dulac O, Takahashi T
Handb Clin Neurol 2013;111:681-9. doi: 10.1016/B978-0-444-52891-9.00070-1. PMID: 23622215
Epilepsy.
Gilligan B
Aust Fam Physician 1979 Feb;8(2):179-94. PMID: 106817

Clinical prediction guides

Acute symptomatic seizures secondary to myelin oligodendrocyte glycoprotein antibody-associated disease.
Montalvo M, Khattak JF, Redenbaugh V, Britton J, Sanchez CV, Datta A, Tillema JM, Chen J, McKeon A, Pittock SJ, Flanagan EP, Dubey D
Epilepsia 2022 Dec;63(12):3180-3191. Epub 2022 Oct 14 doi: 10.1111/epi.17424. PMID: 36168809Free PMC Article
Anticonvulsant activity of methanolic extract of Withania cogulans in mice.
Khattak ZF, Ansari B, Jamal M, Awan AA, Sherkheli MA, Ul Haq R
Metab Brain Dis 2021 Dec;36(8):2437-2443. Epub 2021 Oct 7 doi: 10.1007/s11011-021-00850-0. PMID: 34618296
Pharmacology of lacosamide: From its molecular mechanisms and pharmacokinetics to future therapeutic applications.
Carona A, Bicker J, Silva R, Fonseca C, Falcão A, Fortuna A
Life Sci 2021 Jun 15;275:119342. Epub 2021 Mar 11 doi: 10.1016/j.lfs.2021.119342. PMID: 33713668
The clinico-radiological spectrum of Dyke-Davidoff-Masson syndrome in adults.
Ayas ZÖ, Asil K, Öcal R
Neurol Sci 2017 Oct;38(10):1823-1828. Epub 2017 Jul 21 doi: 10.1007/s10072-017-3074-7. PMID: 28733757
Sudden unexpected death in epilepsy. Potential role of antiepileptic drugs.
Hesdorffer DC, Tomson T
CNS Drugs 2013 Feb;27(2):113-9. doi: 10.1007/s40263-012-0006-1. PMID: 23109241

Recent systematic reviews

Seizures in autoimmune encephalitis: specific features based on a systematic comparative study.
Cousyn L, Lambrecq V, Houot M, Shor N, Nguyen-Michel VH, Frazzini V, Dupont S, Demeret S, Navarro V
Epileptic Disord 2021 Dec 1;23(6):879-892. doi: 10.1684/epd.2021.1355. PMID: 34704941
De novo late-onset absence status epilepticus or late-onset idiopathic generalized epilepsy? A case report and systematic review of the literature.
Brigo F, Tavernelli V, Nardone R, Trinka E
Epileptic Disord 2018 Apr 1;20(2):123-131. doi: 10.1684/epd.2018.0961. PMID: 29620008

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